Human Embryonic Stem Cell–Derived Cardiomyocytes
نویسندگان
چکیده
منابع مشابه
Consensus Comparative Analysis of Human Embryonic Stem Cell-Derived Cardiomyocytes
Global transcriptional analyses have been performed with human embryonic stem cells (hESC) derived cardiomyocytes (CMs) to identify molecules and pathways important for human CM differentiation, but variations in culture and profiling conditions have led to greatly divergent results among different studies. Consensus investigation to identify genes and gene sets enriched in multiple studies is ...
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Cell-autonomous circadian oscillations strongly influence tissue physiology and pathophysiology of peripheral organs including the heart, in which the circadian clock is known to determine cardiac metabolism and the outcome of for instance ischemic stress. Human pluripotent stem cells represent a powerful tool to study developmental processes in vitro, but the extent to which human embryonic st...
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Back ground: Although the cell differentiation is an inseparable part of development in multicellular organisms, the regulating molecular pathway of it still is not fully defined. In the other hand, apoptosis is a fundamental physiological process which plays an essential role in a variety of biological events during development. Moreover, recent studies have found that apoptosis shows several ...
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I.S. Cohen and G.R. Gaudette (eds.), Regenerating the Heart, Stem Cell Biology and Regenerative Medicine, DOI 10.1007/978-1-61779-021-8_2, © Springer Science+Business Media, LLC 2011 Abstract Many forms of heart disease are associated with a decrease in the number of functional cardiomyocytes. These include congenital defects (e.g. hypoplastic and noncompaction syndromes) as well as acquired in...
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in spite of serious cardiotoxicity side-effects, doxorubicin is frequently used for treatment of several types of cancers. isolated human adult cardiomyocytes could be the best model for assessing drug-induced cardiotoxicity, while harvesting mature cardiomyocytes is restricted by some limitations such as biopsy size, cell numbers, viability, proliferative capacity and their disability to be pa...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2019
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.119.314869